Thanks to Seano I have been using Google Chrome to make my life easier. How you ask? Well, Chrome has a really nice bookmarking feature that will allow you to create a standalone instance of Chrome for what ever bookmarked site you want. I use it religiously for Pandora , Google reader, Whos.amung.us, hulu, and gmail.
The process is pretty simple, make sure you have Chrome installed, open and browse to the website you would like to bookmark.
Just left of the address bar is a button, click that and you will get a drop down list of options. Click on “Create application shortcuts…” and you get the below dialog box. In my case, I am creating a “Quick launch bar shortcut for Last.fm, the other options are “Start menu” and “Desktop.”
After you hit ok you while now see you newly create shortcut:
Update: Rey points out that this feature has been available for Firefox in the form of a plugin for some time via the Prism add-on found here: https://addons.mozilla.org/en-US/firefox/addon/6665